COVID-19 Publications

SARS-CoV-2 and the lessons we have to learn from it.

Coronaviruses: The Next Disease X?

The science of soap – here’s how it kills the coronavirus

COVID-19 Update 8: Zinc and chloroquine for the treatment of COVID-19?

The many variables in calculating How likely are you to die of coronavirus - UnHerd

Why do dozens of diseases wax and wane with the seasons—and will COVID-19? ( Excellent food for thought on this area of study)

Thankfully Northern Ireland was not so densely populated and people had warning from what was happening in other countries. Other regions are not so fortunate in this first wave. The lesser hit regions should really be fully utilised to help in this global pandemic.

General Coronavirus

Regulation of Stress Responses and Translational Control by Coronavirus (July 2016)

Abstract - Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.

Medical Ventilators

Treating patients needing requires significant training, some ventilators are surprisingly complicated (See Mechanical ventilation on this Page) If you have experience in ventilation training, can you help assess which training content might be useful in the international Covid19 battle.?

Other Areas

Droplet v Airborne Transmission

The good news it appears there has been no indication of large percentages of shop till staff dis-proportionally being infected with Covid19, it's not likely fully airborne in normal circumstances See (droplet not aerosol) However it is likely critical to ensure equipment such as ventilators connected & some air conditioning systems have adequate filtration.

Airborne Infections

Airborne spread of infectious agents in the indoor environment Author panelJianjianWeiPhDYuguoLiPh

HF21 emergency Solutions

Since the beginning of COVID19 (hindered /delayed by extremely frustrating human obstacles) we have being making frantic efforts to adapt existing plans, prototypes & concepts for this battle. This includes weeks of frantic efforts to urgently improve safety for brave front end medical staff by developing a range of workaround pandemic filters for medical equipment (Which face supply issues), applications for these include hospital & work environments.

Thanks to having a head start in our decade of passionate R&D commitment (which included high precision filtering and fatty lipid membrane Lysis (destruction ) we actually managed to deduce a very simple base solution, so simple it can be assembled with basic items available in most parts of the world. (For a basic demonstration please use the number in the contact page) The challenges include optimising & adapting fittings to a range of equipment air exhalation & exhaust ports, that will involve a team effort.

We wish to develop & produce these under a Patents for Humanity framework or Patents for pandemics in this extremely urgent global emergency. For more see the Emergency R&D page